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pentobarbital will lower the level or impact of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers could lead into a lessen in fentanyl plasma concentrations, lack of efficacy or, perhaps, growth of a withdrawal syndrome in a individual who may have pro